genetic engineering

His body horror films like 'The Fly' and 'Videodrome' obsessively explore the grotesque transformation and mutation of human flesh through technological and biological intervention.

His 'Alien' franchise and films like 'Prometheus' examine the consequences of genetic creation, artificial life, and humanity's hubris in playing God through bioengineering.

His thoughtful science fiction works, particularly 'Blade Runner 2049,' deeply interrogate what it means to be human when genetic replication and artificial creation blur the boundaries of identity.