human mutation

His body horror films like 'The Fly' and 'Videodrome' obsessively explore physical and psychological mutation as inevitable consequences of technology and desire.

His visceral filmmaking in works like 'The Fountain' and 'mother!' depicts transformation and mutation of the human form through obsession, decay, and rebirth.

His anime masterpiece 'Neon Genesis Evangelion' deeply examines human mutation, biological transformation, and the dissolution of individual identity through existential horror.