His surrealist films like Mulholland Drive and Eraserhead explore fractured identities, psychological disintegration, and the blurred boundaries between reality and delusion.

His works such as L'Avventura and Blow-Up examine alienation and the dissolution of self in modern society through fragmented narratives and detached protagonists.

Films like Eternal Sunshine of the Spotless Mind and Synecdoche, New York deconstruct personal identity through meta-narrative, memory loss, and existential confusion.