mutants and mutations

His body horror films like 'The Fly' and 'Videodrome' obsessively explore biological mutation and transformation as metaphors for technology, disease, and human vulnerability.

He consistently portrays mutants and mutations with philosophical depth in films like 'The Shape of Water' and 'Pan's Labyrinth,' treating them as sympathetic outsiders rather than monsters.

His surrealist narratives in 'Eraserhead' and 'The Elephant Man' blur the line between mutation and identity, using physical transformation to explore psychological and existential themes.