prescription drug abuse

His film 'Requiem for a Dream' is a visceral exploration of addiction including prescription drug abuse, depicting the psychological and physical devastation through experimental cinematography.

His films like 'Tangerine' and 'Red Rocket' examine the lives of marginalized individuals struggling with substance abuse and addiction in contemporary America with empathetic realism.

Her film 'The Invitation' and other works explore psychological trauma and dependency, with particular attention to how prescription medications intersect with emotional manipulation and control.