His films consistently explore the consequences of scientific ambition through tension between discovery and human cost, as seen in Arrival, Blade Runner 2049, and Dune.
David Cronenberg CanadaHe pioneered body horror cinema to examine how scientific ambition transforms and corrupts the human body, from The Fly to eXistenZ.
Andrei Tarkovsky Soviet UnionHis philosophical sci-fi masterpieces like Stalker and Solaris probe the metaphysical limits of scientific knowledge and humanity's yearning to transcend them.