His body horror films like 'The Fly' and 'Videodrome' explore the desperation of scientists and subjects confronting the grotesque consequences of their own research.
Andrei Tarkovsky Soviet UnionFilms like 'Stalker' and 'Solaris' examine the desperate human yearning to understand the unknowable and the existential despair when scientific knowledge fails to answer fundamental questions.
Denis Villeneuve CanadaHis work in 'Arrival' and 'Enemy' portrays characters caught in desperate struggles against incomprehensible scientific phenomena and the limits of human understanding.